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Similar findings were also observed in rat hepatoma tissues [18] and human HCC tissue [19,20] as compared to non-HCC tissues

IL-1 ubiquitylation on lysine K133 promotes IL-1 turnover, and loss of IL-1 K133 ubiquitylation via the generation of Il1b K133R/K133R mice enhances i) pro-IL-1 protein levels, ii) the capacity of IL-1 to be activated following NLRP3 triggering, and iii) increases levels of precursor and activated IL-1 following LPS injection

doi: 10.3390/ani13010097 29

When using citrulline with glutathione, glutathione prevents NO degradation as an antioxidant and forms GSNO that acts as a NO donor, which contributes to keeping NO levels high